May 18th, 2015

Nanoparticle radio-sensitizers are nanoscale compounds, typically composed of rare metals such as coated gold, platinum, or gadolinium. Alternatives sensitizers could be made of carbon-based nanostructures, such as fullerenes or nanotubes, provided they are biocompatible and non-toxic. Previous studies have revealed that gold and platinum nanoparticles produce a large number of electrons via the plasmon excitation mechanism. In the case of a carbon nanoparticle, this phenomenon yields electrons with higher energy than pure metals, thus inducing greater biological damage.
In this study, the authors analysed the spectra of secondary electrons emitted from a carbon nanoparticle composed of fullerite, a crystalline form of C60 fullerene, irradiated by an ion beam consisting of fast protons. They quantified the electron yield in a broad kinetic energy range, using several different theoretical and numerical approaches. They found that a medium with an embedded carbon nanoparticle results in a number of low-energy electrons several times higher than that emitted by pure water. This may lead to the development of novel types of sensitizers composed of metallic and carbon-based parts.